Leishmania has a plastic genome, and drug pressure can select for gene copy number
variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to …

The use of next generation sequencing has the power to expedite the identification of drug
resistance determinants and biomarkers and was applied successfully to drug resistance …

Trypanosomatids are a group of kinetoplastid parasites including some of great public
health importance, causing debilitating and life-long lasting diseases that affect more than …

Highlights•Quiescence is associated with differentiation in Leishmania spp.•RNA and
protein reprogramming is necessary for differentiation in Leishmania spp.•RNA and protein …

For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried
out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well …

Leishmania is a digenetic protozoan parasite causing leishmaniasis in humans. The
different clinical forms of leishmaniasis are caused by more than twenty species of …

L eishmania infantum promastigotes differentiate into amastigote forms within the
phagolysosome of mammalian macrophages causing visceral leishmaniasis. Delta …

The degradation of eukaryotic mRNAs can be initiated by deadenylation, decapping, or
endonuclease cleavage. This is followed by 5′–3′ degradation by homologs of Xrn1 …

Among trypanosomatid protozoa the mechanism of RNA interference (RNAi) has been
investigated in T rypanosoma brucei and to a lesser extent in L eishmania braziliensis …

The procyclic form of Trypanosoma brucei colonises the gut of its insect vector, the tsetse fly.
GPEET and EP procyclins constitute the parasite's surface coat at this stage of the life cycle …