Early-onset Alzheimer's disease (EOAD) is a rare but particularly devastating form of AD.
Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same …

Growing evidence has indicated that iron deposition is one of the key factors leading to
neuronal death in the neurodegenerative diseases. Ferritin is a hollow iron storage protein …

The human brain is composed of functional networks that have a modular topology, where
brain regions are organized into communities that form internally dense (segregated) and …

Background Alzheimer's disease (AD) is the most frequent and costly neurodegenerative
disorder. Although diverse lines of evidence suggest that the amyloid precursor protein …

Alzheimer's disease (AD) is characterized by amyloid (Aβ) protein aggregation and
neurofibrillary tangles accumulation, accompanied by neuroinflammation. With all the …

Background Neuroimaging studies of autosomal dominant Alzheimer's disease (ADAD)
enable characterization of the trajectories of cerebral amyloid-β (Aβ) and tau accumulation …

Approximately 5% of Alzheimer's disease cases have an early age at onset (< 65 years),
with 5–10% of these cases attributed to dominantly inherited mutations and the remainder …

Histopathological reports suggest that subregions of the thalamus, which regulates multiple
physiological and cognitive processes, are not uniformly affected by Alzheimer's disease …

Adenosine receptors are attractive therapeutic targets for multiple conditions, including
ischemia-reperfusion injury and neuropathic pain. Adenosine receptor drug discovery efforts …

Opiate abuse is prevalent among HIV-infected individuals and may exacerbate HIV-
associated age-related neurocognitive disorders. However, the extent to which HIV and …