2-Deoxystreptamine: central scaffold of aminoglycoside antibiotics
GF Busscher, FPJT Rutjes, FL Van Delft - Chemical reviews, 2005 - ACS Publications
A key structural feature of the aminoglycoside antibiotics is a 1, 3-diaminocyclohexanetriol
termed streptamine or, in cases where the 2-hydroxy function is deoxygenated as in most …
termed streptamine or, in cases where the 2-hydroxy function is deoxygenated as in most …
Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds
PM Flatt, T Mahmud - Natural product reports, 2007 - pubs.rsc.org
Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds - Natural
Product Reports (RSC Publishing) DOI:10.1039/B603816F Royal Society of Chemistry View PDF …
Product Reports (RSC Publishing) DOI:10.1039/B603816F Royal Society of Chemistry View PDF …
Biosynthetic genes for aminoglycoside antibiotics
Biosynthetic studies of aminoglycoside antibiotics have progressed remarkably during the
last decade. Many biosynthetic gene clusters for aminoglycoside antibiotics including …
last decade. Many biosynthetic gene clusters for aminoglycoside antibiotics including …
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation
JW Park, SR Park, KK Nepal, AR Han, YH Ban… - Nature chemical …, 2011 - nature.com
Kanamycin is one of the most widely used antibiotics, yet its biosynthetic pathway remains
unclear. Current proposals suggest that the kanamycin biosynthetic products are linearly …
unclear. Current proposals suggest that the kanamycin biosynthetic products are linearly …
Novel enzymatic mechanisms in carbohydrate metabolism
X He, G Agnihotri, H Liu - Chemical reviews, 2000 - ACS Publications
Carbohydrates form the most abundant group of natural products and are found in all
classes of living organisms. 1-8 They serve as a direct link between the energy of the sun …
classes of living organisms. 1-8 They serve as a direct link between the energy of the sun …
Detailed reaction mechanism of macrophomate synthase: extraordinary enzyme catalyzing five-step transformation from 2-pyrones to benzoates
K Watanabe, T Mie, A Ichihara, H Oikawa… - Journal of Biological …, 2000 - ASBMB
Macrophomate synthase from the fungusMacrophoma commelinae IFO 9570 is a Mg (II)-
dependent dimeric enzyme that catalyzes an extraordinary, complex five-step chemical …
dependent dimeric enzyme that catalyzes an extraordinary, complex five-step chemical …
Aminoglycoside antibiotics: new insights into the biosynthetic machinery of old drugs
Deoxystreptamine (2DOS) is the unique chemically stable aminocyclitol scaffold of clinically
important aminoglycoside antibiotics such as neomycin, kanamycin, and gentamicin, which …
important aminoglycoside antibiotics such as neomycin, kanamycin, and gentamicin, which …
Butirosin-biosynthetic gene cluster from Bacillus circulans
Y Ota, H Tamegai, F Kudo, H Kuriki… - The Journal of …, 2000 - jstage.jst.go.jp
Butirosin-biosynthetic GeneCluster from Bacillus circulans Page 1 VOL.53 NO. 10, OCT.2000
THE JOURNAL OF ANTIBIOTICS Butirosin-biosynthetic GeneCluster from Bacillus circulans …
THE JOURNAL OF ANTIBIOTICS Butirosin-biosynthetic GeneCluster from Bacillus circulans …
Isolation and characterization of the tobramycin biosynthetic gene cluster from Streptomyces tenebrarius
The biosynthetic gene cluster for tobramycin, a 2-deoxystreptamine-containing
aminoglycoside antibiotic, was isolated from Streptomyces tenebrarius ATCC 17920. A …
aminoglycoside antibiotic, was isolated from Streptomyces tenebrarius ATCC 17920. A …
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster
Gene clusters for the biosynthesis of kanamycin (Km) and gentamicin (Gm) were isolated
from the genomic libraries of Streptomyces kanamyceticus and Micromonospora …
from the genomic libraries of Streptomyces kanamyceticus and Micromonospora …