Innovative chemical tools to address analytical challenges of protein phosphorylation and glycosylation

M Li, Y Xiong, G Qing - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Protein post-translational modifications (PTMs) modulate almost all cellular
processes. Aberrant PTMs are closely bound to various human diseases, which greatly …

Recent advances in glycoproteomic analysis by mass spectrometry

S Suttapitugsakul, F Sun, R Wu - Analytical chemistry, 2019 - ACS Publications
Glycosylation is one of the most common protein modifications and is essential for cells. This
modification is exceptionally complex because glycans are highly diverse and can be …

Quantification of protein glycosylation using nanopores

RCA Versloot, FLR Lucas, L Yakovlieva… - Nano Letters, 2022 - ACS Publications
Although nanopores can be used for single-molecule sequencing of nucleic acids using low-
cost portable devices, the characterization of proteins and their modifications has yet to be …

Global and site‐specific analysis of protein glycosylation in complex biological systems with Mass Spectrometry

H Xiao, F Sun, S Suttapitugsakul… - Mass spectrometry …, 2019 - Wiley Online Library
Protein glycosylation is ubiquitous in biological systems and plays essential roles in many
cellular events. Global and site‐specific analysis of glycoproteins in complex biological …

[HTML][HTML] Molecular imprinting of glycoproteins: From preparation to cancer theranostics

MM Ali, S Zhu, FR Amin, D Hussain, Z Du, L Hu - Theranostics, 2022 - ncbi.nlm.nih.gov
Glycoprotein imprinted polymers have rapidly grown as excellent receptors for cancer
targeting, diagnostics, inhibition, and nanomedicines as they specifically target glycans and …

Towards structure-focused glycoproteomics

A Chernykh, R Kawahara… - Biochemical Society …, 2021 - portlandpress.com
Facilitated by advances in the separation sciences, mass spectrometry and informatics,
glycoproteomics, the analysis of intact glycopeptides at scale, has recently matured enabling …

Facile preparation of hydrophilic mesoporous metal–organic framework via synergistic etching and surface functionalization for glycopeptides analysis

C Pu, H Zhao, Y Hong, Q Zhan, M Lan - Analytical chemistry, 2019 - ACS Publications
In view of the size and hydrophilicity of glycopeptides, materials having suitable channels
(size-exclusion) and strong hydrophilic surface (hydrophilic interaction) are preferred to …

A facilely synthesized glutathione-functionalized silver nanoparticle-grafted covalent organic framework for rapid and highly efficient enrichment of N-linked …

YF Ma, LJ Wang, YL Zhou, XX Zhang - Nanoscale, 2019 - pubs.rsc.org
The development of facilely synthetic materials for highly efficient enrichment of N-linked
glycopeptides is essential in glycoproteome analysis. In this work, by utilizing the self …

[HTML][HTML] Roles of the exosomes derived from myeloid-derived suppressor cells in tumor immunity and cancer progression

Z Chen, R Yuan, S Hu, W Yuan, Z Sun - Frontiers in immunology, 2022 - frontiersin.org
Tumor immunity is involved in malignant tumor progression. Myeloid-derived suppressor
cells (MDSCs) play an irreplaceable role in tumor immunity. MDSCs are composed of …

Janus nanozyme based satellite structure immunosandwich colorimetric strategy for glycoproteins visual detection

YD Zhang, C Ma, YP Shi - Chemical Engineering Journal, 2023 - Elsevier
Glycoproteins are reliable biomarkers for early cancer detection, and the timely response to
these biomarkers could improve the survival rate and reduce the medical care burden …