Atopic dermatitis (AD) is a multifactorial, heterogeneous disease characterized by epidermal
barrier dysfunction, immune system dysregulation, and skin microbiome alterations. Skin …

The sensory nervous system possesses the ability to integrate exogenous threats and
endogenous signals to mediate downstream effector functions. Sensory neurons have been …

Neutrophils are heterogeneous, but the mechanisms underlying their ability to polarize
remain unclear. In this issue of Immunity, Gour et al. demonstrate that the GPCR Mrgpra1 …

Pruritus or itch is a defining symptom of atopic dermatitis (AD). The origins of itch are
complex, and it is considered both a defense mechanism and a cause of disease that leads …

Peripheral sensory neurons recognize diverse noxious stimuli, including microbial products
and allergens traditionally thought to be targets of the mammalian immune system …

The interplay between the skin microbiome and its host is a complex facet of dermatological
health and has become a critical focus in the development of microbiome cosmetics. The …

Background Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with
skin barrier defects and a misdirected type 2 immune response against harmless antigens …

The skin microbiome is an extensive community of bacteria, fungi, mites, viruses and
archaea colonizing the skin. Fluctuations in the composition of the skin microbiome have …

Introduction Atopic dermatitis (AD) is an inflammatory skin condition that affects millions of
pediatric and adult patients with well-studied impact on morbidity and quality of life …

In a recent issue of Cell, Deng et al. show that S. aureus serine protease V8 triggers itch,
independent of inflammation, by activating sensory neurons through PAR1. This study …