Objectives Organ-specific hemosiderosis and iron overload complications are more serious
and more frequent in some patients with beta thalassemia major (BTM) compared with …

AIM: This study aimed to detect the most common HFE gene mutations (C282Y, H63D, and
S56C) in Egyptian beta thalassemia major patients and its relation to their iron status …

The human hemochromatosis protein HFE is encoded by the HFE gene and participates in
iron regulation. The aim of this study was to detect the most frequent HFE gene mutations in …

Background Iron overload represents a consistent and almost inevitable complication in
patients with transfusion-dependent β-thalassemia. The frequently needed erythrocyte …

Frequency of hereditary hemochromatosis gene mutations and their effects on iron overload
among beta thalassemia patients of Che Page 1 AIMS Molecular Science, 8(4): 233–247. DOI …

Background HFE gene mutations have been shown to be responsible for hereditary
hemochromatosis. Their effect on iron load in β-thalassemia patients and carriers remains …

Background: Thalassemia patients need repeated transfusion that lead to increased blood
ferritin level and iron overload in the heart and liver. Because the roles of hepcidin …

Hereditary hemochromatosis and β-thalassemia can both result in the inappropriately low
production of the hormone hepcidin, which leads to an increase in intestinal absorption and …

Mutations of the HAMP gene and HFE gene have a role in iron overload. We assessed the
frequency of the G71D mutation of the HAMP gene and the H63D mutation of the HFE gene …

地中海贫血是一种常见的常染色体隐性遗传病, 是由某个或多个珠蛋白基因异常引起一种或一种
以上珠蛋白肽链合成减少或缺乏的溶血性贫血. 地中海贫血长期的慢性溶血 …