How introns enhance gene expression
O Shaul - The international journal of biochemistry & cell biology, 2017 - Elsevier
In many eukaryotes, including mammals, plants, yeast, and insects, introns can increase
gene expression without functioning as a binding site for transcription factors. This …
gene expression without functioning as a binding site for transcription factors. This …
[HTML][HTML] Butyrate protects mice from Clostridium difficile-induced colitis through an HIF-1-dependent mechanism
Antibiotic-induced dysbiosis is a key factor predisposing intestinal infection by Clostridium
difficile. Here, we show that interventions that restore butyrate intestinal levels mitigate …
difficile. Here, we show that interventions that restore butyrate intestinal levels mitigate …
Genome-Wide Analysis of mRNA Decay Rates and Their Determinants in Arabidopsis thaliana
To gain a global view of mRNA decay in Arabidopsis thaliana, suspension cell cultures were
treated with a transcriptional inhibitor, and microarrays were used to measure transcript …
treated with a transcriptional inhibitor, and microarrays were used to measure transcript …
New insights into the expression and functions of the Kaposi's sarcoma-associated herpesvirus long noncoding PAN RNA
NK Conrad - Virus research, 2016 - Elsevier
The Kaposi's sarcoma-associated herpesvirus (KSHV) is a clinically relevant pathogen
associated with several human diseases that primarily affect immunocompromised …
associated with several human diseases that primarily affect immunocompromised …
Polysome propensity and tunable thresholds in coding sequence length enable differential mRNA stability
The half-life of mRNAs, as well as their translation, increases in proportion to the optimal
codons, indicating a tight coupling of codon-dependent differential translation and …
codons, indicating a tight coupling of codon-dependent differential translation and …
Arabidopsis mRNA decay landscape arises from specialized RNA decay substrates, decapping-mediated feedback, and redundancy
RS Sorenson, MJ Deshotel… - Proceedings of the …, 2018 - National Acad Sciences
The decay of mRNA plays a vital role in modulating mRNA abundance, which, in turn,
influences cellular and organismal processes. In plants and metazoans, three distinct …
influences cellular and organismal processes. In plants and metazoans, three distinct …
Introns within ribosomal protein genes regulate the production and function of yeast ribosomes
In budding yeast, the most abundantly spliced pre-mRNAs encode ribosomal proteins (RPs).
To investigate the contribution of splicing to ribosome production and function, we …
To investigate the contribution of splicing to ribosome production and function, we …
Distinct patterns of expression and evolution of intronless and intron-containing mammalian genes
SA Shabalina, AY Ogurtsov… - Molecular biology …, 2010 - academic.oup.com
Abstract Comparison of expression levels and breadth and evolutionary rates of intronless
and intron-containing mammalian genes shows that intronless genes are expressed at …
and intron-containing mammalian genes shows that intronless genes are expressed at …
A super minigene with a short promoter and truncated introns recapitulates essential features of transcription and splicing regulation of the SMN1 and SMN2 genes
Here we report a Survival Motor Neuron 2 (SMN2) super minigene, SMN2Sup,
encompassing its own promoter, all exons, their flanking intronic sequences and the entire …
encompassing its own promoter, all exons, their flanking intronic sequences and the entire …
Characterizing RNA stability genome-wide through combined analysis of PRO-seq and RNA-seq data
Background The concentrations of distinct types of RNA in cells result from a dynamic
equilibrium between RNA synthesis and decay. Despite the critical importance of RNA …
equilibrium between RNA synthesis and decay. Despite the critical importance of RNA …