Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting
step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is …

Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …

Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different
subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly …

Background: The adult mammalian heart has limited regenerative capacity, mostly
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …

Background Heat shock protein 90 (HSP90) functions as a well-known onco-protein to
regulate protein conformation, stability and degradation. Pyruvate kinase M2 (PKM2), a …

Cancer cells can adapt to low energy sources in the face of ATP depletion as well as to their
high levels of ROS by altering their metabolism and energy production networks which might …

It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even
in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor …

We investigated the metabolic profile of cancer stem cells (CSC) isolated from patients with
epithelial ovarian cancer. CSC overexpressed genes associated with glucose uptake …

Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the
human genome. Besides their participation to normal physiology, lncRNA expression and …

The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …