Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer
The tumour stroma regulates nearly all stages of carcinogenesis. Stromal heterogeneity in
human triple‐negative breast cancers (TNBCs) remains poorly understood, limiting the …
human triple‐negative breast cancers (TNBCs) remains poorly understood, limiting the …
[HTML][HTML] COUP-TFII in health and disease
S Polvani, S Pepe, S Milani, A Galli - Cells, 2019 - mdpi.com
The nuclear receptors (NRs) belong to a vast family of evolutionary conserved proteins
acting as ligand-activated transcription factors. Functionally, NRs are essential in …
acting as ligand-activated transcription factors. Functionally, NRs are essential in …
[HTML][HTML] Skeletal muscle transcriptome in healthy aging
Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect
accumulation of damage and compensatory adaptations to preserve tissue integrity. To …
accumulation of damage and compensatory adaptations to preserve tissue integrity. To …
[HTML][HTML] New insights into the diverse functions of the NR2F nuclear orphan receptor family
T Sajinovic, G Baier - Frontiers in Bioscience-Landmark, 2023 - imrpress.com
Following gene expansion during evolution, today's phylogenetic tree of the NR2F family of
nuclear orphan receptors in mammals is represented by three different isoforms: NR2F1 …
nuclear orphan receptors in mammals is represented by three different isoforms: NR2F1 …
iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling
D Guo, K Daman, JJC Chen, MJ Shi, J Yan… - Elife, 2022 - elifesciences.org
Skeletal muscle myoblasts (iMyoblasts) were generated from human induced pluripotent
stem cells (iPSCs) using an efficient and reliable transgene-free induction and stem cell …
stem cells (iPSCs) using an efficient and reliable transgene-free induction and stem cell …
[HTML][HTML] DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults
MA Burton, ES Garratt, MO Hewitt, HY Sharkh… - Skeletal Muscle, 2023 - Springer
Background While ageing is associated with increased insulin resistance (IR), the molecular
mechanisms underlying increased IR in the muscle, the primary organ for glucose …
mechanisms underlying increased IR in the muscle, the primary organ for glucose …
Developmentally linked human DNA hypermethylation is associated with down-modulation, repression, and upregulation of transcription
ABSTRACT DNA methylation can affect tissue-specific gene transcription in ways that are
difficult to discern from studies focused on genome-wide analyses of differentially …
difficult to discern from studies focused on genome-wide analyses of differentially …
[HTML][HTML] Beneficial effects of β-escin on muscle regeneration in rat model of skeletal muscle injury
M Sikorska, M Dutkiewicz, O Zegrocka–Stendel… - Phytomedicine, 2021 - Elsevier
Background Recent advancements in understanding β-escin action provide basis for new
therapeutic claims for the drug. β-escin-evoked attenuation of NF-κB-dependent signaling …
therapeutic claims for the drug. β-escin-evoked attenuation of NF-κB-dependent signaling …
Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway
Alternative lengthening of telomeres (ALT) is known to use homologous recombination (HR)
to replicate telomeric DNA in a telomerase-independent manner. However, the detailed …
to replicate telomeric DNA in a telomerase-independent manner. However, the detailed …
COUP-TFII revisited: Its role in metabolic gene regulation
UM Ashraf, ER Sanchez, S Kumarasamy - Steroids, 2019 - Elsevier
Abstract Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) is an
orphan member of the nuclear receptor family of transcriptional regulators. Although …
orphan member of the nuclear receptor family of transcriptional regulators. Although …