Global impacts of western diet and its effects on metabolism and health: A narrative review

VJ Clemente-Suárez, AI Beltrán-Velasco… - Nutrients, 2023 - mdpi.com
The Western diet is a modern dietary pattern characterized by high intakes of pre-packaged
foods, refined grains, red meat, processed meat, high-sugar drinks, candy, sweets, fried …

The burden of carbohydrates in health and disease

VJ Clemente-Suárez, J Mielgo-Ayuso… - Nutrients, 2022 - mdpi.com
Foods high in carbohydrates are an important part of a healthy diet, since they provide the
body with glucose to support bodily functions and physical activity. However, the abusive …

[HTML][HTML] Deciphering the emerging role of programmed cell death in diabetic wound healing

J Song, K Zhu, H Wang, M Wu, Y Wu… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Diabetic wounds are characterized by delayed and incomplete healing. As one of the most
common complications of diabetes, diabetic wounds can be fatal in some cases …

Increased α-HB links colorectal cancer and diabetes by potentiating NF-κB signaling

X Lv, P Ding, L Li, L Li, D Zhou, X Wang, J Chen… - Molecular …, 2023 - Elsevier
Sufficient evidence has linked many different types of cancers and T2D through shared risk
factors; however, the underlying mechanisms are not fully understood. α-Hydroxybutyrate (α …

Repurposing metformin for cancer treatment: a great challenge of a promising drug

C Saengboonmee, T Sanlung… - Anticancer …, 2021 - ar.iiarjournals.org
The safety windows and toxicity of clinically available known drugs allow drug repurposing
to be a popular treatment strategy for several diseases, including cancers. Several common …

[HTML][HTML] Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

M Liao, D Yao, L Wu, C Luo, Z Wang, J Zhang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Cancer reprogramming is an important facilitator of cancer development and survival, with
tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation …

Could Metformin and Resveratrol Support Glioblastoma Treatment? A Mechanistic View at the Cellular Level

RS Ibrahim, SS Ibrahim, A El-Naas, L Koklesová… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma's poor prognosis calls for the discovery of newer, more
efficacious management and treatment methods. This review collates and examines how the …

High glucose promotes pancreatic ductal adenocarcinoma gemcitabine resistance and invasion through modulating ROS/MMP‐3 signaling pathway

J Deng, Y Guo, X Hu, J Du, J Gu, L Kong… - Oxidative Medicine …, 2022 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDA) is often concomitant with diabetes mellitus, which
mainly manifests as an increased blood glucose level. Previous studies revealed that …

Kidney proximal tubule GLUT2—more than meets the eye

M Ahmad, I Abramovich, B Agranovich, A Nemirovski… - Cells, 2022 - mdpi.com
Tubulopathy plays a central role in the pathophysiology of diabetic kidney disease (DKD).
Under diabetic conditions, the kidney proximal tubule cells (KPTCs) are exposed to an …

Personalizing nutrition strategies: bridging research and public health

VJ Clemente-Suárez, HC Peris-Ramos… - Journal of Personalized …, 2024 - mdpi.com
In recent years, although life expectancy has increased significantly, non-communicable
diseases (NCDs) continue to pose a significant threat to the health of the global population …