The volume of interstitial fluid (ISF) in the human body is three times that of blood. Yet,
collecting diagnostically useful ISF is more challenging than collecting blood because the …

The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

A combination of extrinsic (passive) and intrinsic (active) forces move lymph against a
hydrostatic pressure gradient in most regions of the body. The effectiveness of the lymph …

The supply of oxygen and nutrients to tissues is performed by the blood system and involves
a net leakage of fluid outward at the capillary level. One of the principal functions of the …

The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that
comprise the cellular microenvironment in tissues. Its alterations are fundamental to …

The lymphatic vasculature is not considered a formal part of the immune system, but it is
critical to immunity. One of its major roles is in the coordination of the trafficking of antigen …

Cervical lymphatic vessels (cLVs) have been shown to drain solutes and cerebrospinal fluid
(CSF) from the brain. However, their hydrodynamical properties have never been evaluated …

Advances in our understanding of the structure and function of the lymphatic system have
made it possible to identify its role in a variety of disease processes. Because it is involved …

The removal of interstitial fluid from the tissues is performed exclusively by the lymphatic
system. Tissue edema in congestive heart failure occurs only when the lymphatic system …

Therapeutic tumor vaccines have attracted considerable attention in the past decade; they
can induce tumor regression, eradicate minimal residual disease, establish lasting immune …