Although major depressive disorder is primarily considered a mood disorder, depressed
patients commonly present with clinically significant cognitive dysfunction that may add to …

Cocaine abuse and addiction remain great challenges on the public health agendas in the
US and the world. Increasingly sophisticated perspectives on addiction to cocaine and other …

Impulsivity is common in Parkinson's disease even in the absence of impulse control
disorders. It is likely to be multifactorial, including a dopaminergic 'overdose'and structural …

Acetylcholine (ACh) is an important neuromodulator in the nervous system implicated in
many forms of cognitive and motor processing. Recent studies have used bacterial artificial …

The subjective measures used to study mood disorders in humans cannot be replicated in
animals; however, the increasing application of objective neuropsychological methods …

Rationale Affective states are known to influence behaviour in humans resulting in cognitive
affective biases, which may play an important role in the development and treatment of …

Research over the last two decades has widely demonstrated that impulsivity, in its various
forms, is antecedent to the development of drug addiction and an important behavioural trait …

Apathy and impulsivity are two major comorbid syndromes of Parkinson's disease (PD) that
may represent two extremes of a behavioral spectrum modulated by dopamine-dependent …

Rationale For many mammals, engaging in social play behavior as a juvenile is important
for cognitive, social, and emotional health as an adult. A playful phenotype reflects a …

Impulsivity is a multidimensional construct, but the relationships between its constructs and
their respective underlying dopaminergic underpinnings in the general population remain …