Advances in bladder cancer biology and therapy

L Tran, JF Xiao, N Agarwal, JE Duex… - Nature Reviews …, 2021 - nature.com
The field of research in bladder cancer has seen significant advances in recent years. Next-
generation sequencing has identified the genes most mutated in bladder cancer. This …

Sequencing-based methods and resources to study antimicrobial resistance

M Boolchandani, AW D'Souza, G Dantas - Nature Reviews Genetics, 2019 - nature.com
Antimicrobial resistance extracts high morbidity, mortality and economic costs yearly by
rendering bacteria immune to antibiotics. Identifying and understanding antimicrobial …

Urinary microbiome: yin and yang of the urinary tract

V Perez-Carrasco, A Soriano-Lerma… - Frontiers in cellular …, 2021 - frontiersin.org
The application of next generation sequencing techniques has allowed the characterization
of the urinary tract microbiome and has led to the rejection of the pre-established concept of …

The microbiome of the urinary tract—a role beyond infection

SA Whiteside, H Razvi, S Dave, G Reid… - Nature Reviews …, 2015 - nature.com
Urologists rarely need to consider bacteria beyond their role in infectious disease. However,
emerging evidence shows that the microorganisms inhabiting many sites of the body …

Advances in understanding the human urinary microbiome and its potential role in urinary tract infection

ML Neugent, NV Hulyalkar, VH Nguyen, PE Zimmern… - MBio, 2020 - Am Soc Microbiol
Recent advances in the analysis of microbial communities colonizing the human body have
identified a resident microbial community in the human urinary tract (UT). Compared to many …

Gram‐positive uropathogens, polymicrobial urinary tract infection, and the emerging microbiota of the urinary tract

KA Kline, AL Lewis - Urinary tract infections: molecular …, 2017 - Wiley Online Library
Uncomplicated urinary‐tract infection (UTI) is most common in young, sexually active,
nonpregnant, premenopausal women. Gram‐negative bacteria are isolated from 75% to …

The female urinary microbiome: a comparison of women with and without urgency urinary incontinence

MM Pearce, EE Hilt, AB Rosenfeld, MJ Zilliox… - MBio, 2014 - Am Soc Microbiol
Bacterial DNA and live bacteria have been detected in human urine in the absence of
clinical infection, challenging the prevailing dogma that urine is normally sterile. Urgency …

Urine is not sterile: use of enhanced urine culture techniques to detect resident bacterial flora in the adult female bladder

EE Hilt, K McKinley, MM Pearce… - Journal of clinical …, 2014 - Am Soc Microbiol
Our previous study showed that bacterial genomes can be identified using 16S rRNA
sequencing in urine specimens of both symptomatic and asymptomatic patients who are …

Culturing of female bladder bacteria reveals an interconnected urogenital microbiota

K Thomas-White, SC Forster, N Kumar… - Nature …, 2018 - nature.com
Metagenomic analyses have indicated that the female bladder harbors an indigenous
microbiota. However, there are few cultured reference strains with sequenced genomes …

The clinical urine culture: enhanced techniques improve detection of clinically relevant microorganisms

TK Price, T Dune, EE Hilt… - Journal of clinical …, 2016 - Am Soc Microbiol
Enhanced quantitative urine culture (EQUC) detects live microorganisms in the vast majority
of urine specimens reported as “no growth” by the standard urine culture protocol. Here, we …