COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of
2019 and was rapidly spread in most countries. This respiratory virus has different symptoms …

The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …

Life is a cyclical chemical process that is regulated in four dimensions. We distinguish parts
of the cycle: development describes the changes from single cell to adult, and aging the …

Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional
induction of a series of genes that participate in angiogenesis, iron metabolism, glucose …

Traditionally considered as a critical intermediate in the toxic and carcinogenic response to
dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, TCDD), the Aryl hydrocarbon/Dioxin receptor …

Gene regulatory networks are the most complex, extensive control systems found in nature.
The interaction between biology and evolution has been the subject of great interest in …

The helix-loop-helix (HLH) family of transcriptional regulatory proteins are key players in a
wide array of developmental processes. Over 240 HLH proteins have been identified to date …

The cellular response to hypoxia includes the hypoxia-inducible factor-1 (HIF-1)-induced
transcription of genes involved in diverse processes such as glycolysis and angiogenesis …

Light is a major environmental signal for circadian rhythms. We have identified and analyzed
cry, a novel Drosophila cryptochrome gene. All characterized family members are directly …

Regulatory DNAs serve as templates to bring weakly interacting transcription factors into
close proximity so they can work synergistically to switch genes on and off in time and …