New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease

F Zhang, R Zhong, C Cheng, S Li, W Le - Acta Pharmacologica Sinica, 2021 - nature.com
As the population ages, Alzheimer's disease (AD), the most common neurodegenerative
disease in elderly people, will impose social and economic burdens to the world. Currently …

Association between statin use and cognitive function: a systematic review of randomized clinical trials and observational studies

A Adhikari, S Tripathy, S Chuzi, J Peterson… - Journal of Clinical …, 2021 - Elsevier
Abstract The US Food and Drug Administration issued a black box warning in 2012
regarding the association of statin use with cognitive impairment. This may deter patients …

What is the impact of ongoing statin use on cognitive decline and dementia progression in older adults with mild-moderate Alzheimer disease?

C Murphy, AH Dyer, B Lawlor, SP Kennelly… - Plos one, 2023 - journals.plos.org
Background In addition to the clear cardiovascular benefit, there has been renewed interest
in the potential of statins in the prevention of cognitive impairment and dementia in older …

Detection of dementia progression from functional activities data using machine learning techniques

F Thabtah, S Ong, D Peebles - Intelligent Decision …, 2022 - content.iospress.com
Early screening for Alzheimer's disease (AD) is crucial for disease management,
intervention, and healthcare resource accessibility. Medical assessments of AD diagnosis …

The Effects of Statins on Cognitive Performance Are Mediated by Low-Density Lipoprotein, C-Reactive Protein, and Blood Glucose Concentrations

M Gentreau, G Rukh, M Miguet… - The Journals of …, 2023 - academic.oup.com
Statins are widely used for cardiovascular disease prevention but their effects on cognition
remain unclear. Statins reduce cholesterol concentration and have been suggested to …

Statins and cognitive decline in patients with Alzheimer's and mixed dementia: a longitudinal registry-based cohort study

B Petek, H Häbel, H Xu, M Villa-Lopez, I Kalar… - Alzheimer's Research & …, 2023 - Springer
Background Disturbances in brain cholesterol homeostasis may be involved in the
pathogenesis of Alzheimer's disease (AD). Lipid-lowering medications could interfere with …

[HTML][HTML] 降脂药物对认知功能影响的综述与前瞻

韩立君, 苏畅, 高聆 - Advances in Clinical Medicine, 2024 - hanspub.org
本综述探讨了降脂药物(包括他汀类, PCSK9 抑制剂, 依折麦布和贝特类)
对认知功能的潜在影响. 尽管有些研究和病例报告提示这些药物可能对认知有不良影响 …

Preventing lethal prostate cancer with diet, supplements, and rx: Heart healthy continues to be prostate healthy and “first do no harm” part II

MA Moyad - Current urology reports, 2020 - Springer
Abstract Purpose of Review To discuss the overall and latest observations of the effect of
diet, lifestyle, supplements, and some prescription heart healthy medications for prostate …

Review of the protective effects of statins on cognition

B Chadha, WH Frishman - Cardiology in Review, 2021 - journals.lww.com
Elevated cholesterol is a major risk factor in the development of cardiovascular disease.
Statins have proven to be effective in lowering low-density lipoprotein cholesterol as well as …

Statins and Alzheimer—current stand and further development directions

A Wełniak, P Koszykowska… - Medical Research …, 2020 - journals.viamedica.pl
In an aging society, more emphasis should be placed on prevention rather than treating
diseases. Alzheimer's disease is a common sickness affecting older people. It is predicted …