Phosphatidylserine (PS) is a major component of membrane bilayers whose change in
distribution between inner and outer leaflets is an important physiological signal. Normally …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

Current understanding of how platelets localize coagulation to wound sites has come mainly
from studies of a subpopulation of activated platelets. In this review, we summarize data from …

Phospholipid (PL) scramblases disrupt the lipid asymmetry of the plasma membrane,
externalizing phosphatidylserine to trigger blood coagulation and mark apoptotic cells …

Phospholipid scrambling (PLS) is a ubiquitous cellular mechanism involving the regulated
bidirectional transport of phospholipids down their concentration gradient between …

Background—Platelets are central to the process of hemostasis, rapidly aggregating at sites
of blood vessel injury and acting as coagulation nidus sites. On interaction with the …

TMEM16A (known as anoctamin 1) Ca 2+-activated chloride channel is overexpressed in
many tumors. TMEM16A overexpression can be caused by gene amplification in many …

Abstract Purinergic P2X7 receptors (P2X7R) are fundamental to innate immune response. In
macrophages, transient stimulation of P2X7R activates several transport mechanisms and …

The TMEM16 family of membrane proteins is composed of both Ca2+-gated Cl− channels
and Ca2+-dependent phospholipid scramblases. The functional diversity of TMEM16s …

As a Ca 2+-activated lipid scramblase and ion channel that mediates Ca 2+ influx,
TMEM16F relies on both functions to facilitate extracellular vesicle generation, blood …