Fluorouracil, or 5-flourouracil (5-FU), is a chemotherapy agent that belongs to the drug class
of fluoropyrimidines. When given as an intravenous (IV) solution, 5-FU is used in the …

Capecitabine (brand name Xeloda) is a chemotherapy agent that belongs to the drug class
of fluoropyrimidines. It is widely used in the treatment of several malignancies including …

Objective (s): Colorectal cancer is the second deadly cancer for men and women worldwide.
Depending on the pathological attributes of the tumor, there are numerous therapeutic …

Although more than half a century has passed since the discovery of fluoropyrimidines, they
are still used in the treatment of many types of cancer, and it is estimated that annually two …

Purpose Fluoropyrimidines, the major chemotherapeutic agents in various malignancies
treatment, are metabolized by dihydropyrimidine dehydrogenase (DPD). DPD deficiency …

Background: With an estimated 1.8 million deaths, lung cancer is one of the widely reported
malignancies, with substantial morbidity and mortality rates. Thymidylate synthase (TS) is an …

In troduction: Colorectal cancer is the most common malignancy of the digestive tract. The
treatment is based on administering antitumor medications, such as 5-fluorouracil (5-FU) …

Pharmacogenomics is a powerful tool to predict individual response to treatment, in order to
personalize therapy, and it has been explored extensively in oncology practice. Not only …

Background: Lung cancer is the first cause of cancer deaths in the world. Pemetrexed is an
antifolate drug used as a first or second-line in the treatment of advanced non-small cell lung …

Breast cancer is a common cancer found among women worldwide. Many polymorphisms
can play a role in the development of this disease. The study was conducted to evaluate …