The nuclear envelope is often depicted as a static barrier that regulates access between the
nucleus and the cytosol. However, recent research has identified many conditions in …

Nuclear lamins are type V intermediate filament proteins that polymerize into complex
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …

INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell,
taste, touch, and proprioception) to help them to react properly to their environment. The …

Tight control of cell fate choices is crucial for normal development. Here we show that lamin
A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which …

Traumatic brain injury (TBI) is distinct from other neurological disorders because it is
induced by a discrete event that applies extreme mechanical forces to the brain. This review …

The nuclear pore complex (NPC) is a large protein assembly that perforates the nuclear
envelope and provides a sole gateway for traffic between the cytoplasm and the nucleus …

Mutations in the gene for lamin A/C (LMNA) cause a diverse range of diseases known as
laminopathies. LMNA-related cardiomyopathy is a common inherited heart disease and is …

Large protein complexes assemble at the nuclear envelope to transmit mechanical signals
between the cytoskeleton and nucleoskeleton. These protein complexes are known as the …

Cells migrate collectively through confined environments during development and cancer
metastasis. The nucleus, a stiff organelle, impedes single cells from squeezing into narrow …

Mutations in the LMNA gene, encoding the nuclear envelope A-type lamins, are responsible
for muscular dystrophies, the most severe form being the LMNA-related congenital muscular …