Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …

Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Phosphoinositides serve crucial roles in cell physiology, ranging from cell signalling to
membrane traffic,. Among the seven eukaryotic phosphoinositides the best studied species …

The quantitatively minor phospholipid phosphatidylinositol (4, 5)-bisphosphate [PI (4, 5) P2]
fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic …

Clathrin-mediated endocytosis is initiated by a network of weakly interacting proteins
through a poorly understood mechanism. Ede1, the yeast homolog of mammalian Eps15, is …

Coated pits assemble by growth of a clathrin lattice, which is linked by adaptors to the
underlying membrane. How does this process start? We used live-cell TIRF imaging with …

Numerous endocytic accessory proteins (EAPs) mediate assembly and maturation of
clathrin-coated pits (CCPs) into cargo-containing vesicles. Analysis of EAP function through …

Phosphoinositides (PIs) are phospholipids that perform crucial cell functions, ranging from
cell migration and signaling to membrane trafficking, by serving as signposts of …

Endocytosis, phagocytosis, and macropinocytosis are fundamental processes that enable
cells to sample their environment, eliminate pathogens and apoptotic bodies, and regulate …