Nuclear magnetic resonance, surface plasmon resonance and fluorescence spectroscopy
(particularly fluorescence anisotropy and fluorescence lifetime) are techniques often applied …

The way in which organisms detect specific volatile compounds within their environment,
and the associated neural processing which produces perception and subsequent …

Computational techniques can speed up the identification of hits and accelerate the
development of candidate molecules for drug discovery. Among techniques for predicting …

Biosensor-based fragment screening is a valuable tool in the drug discovery process. This
method is advantageous over many biochemical methods because primary hits can be …

Fragment-based drug discovery is a validated approach for the discovery of drug
candidates. However, the weak affinity of fragment compounds requires highly sensitive …

The detection and characterization of fragment binding requires the use of technologies with
extreme sensitivity to observe the binding interactions of low-affinity and low-molecular …

Natural products are a rich source of bioactive molecules that have potential
pharmacotherapeutic applications. In this study, we focused on Artemisia annua (A. annua) …

A ProteOn XPR36 parallel array biosensor was used to characterize the binding kinetics of a
set of small molecule/enzyme interactions. Using one injection with the ProteOn's …

Special agents for protein capture: Iterative in situ click chemistry (see scheme for the tertiary
ligand screen) and the one‐bead–one‐compound method for the creation of a peptide …

We performed a systematic comparison of three label‐free methods for quantitative
assessment of binding strengths of proteins interacting with small molecule ligands. The …