The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

Organ transplantation appears today to be the best alternative to replace the loss of vital
organs induced by various diseases. Transplants can, however, also be rejected by the …

Rationale: Frailty is associated with morbidity and mortality in abdominal organ
transplantation but has not been examined in lung transplantation. Objectives: To examine …

Successful lung transplantation has been limited by the high incidence of acute graft
rejection. There is mounting evidence that the stress response gene heme oxygenase-1 (HO …

Chronic lung allograft dysfunction (CLAD) was recently introduced as an overarching term
mainly to classify patients with chronic rejection after lung transplantation, although other …

Lung transplantation is a therapeutic option for patients with end-stage pulmonary disorders.
Unfortunately, chronic lung allograft dysfunction (CLAD), most commonly manifest as …

Background. Chronic human lung allograft rejection, represented by bronchiolitis obliterans
syndrome (BOS), is the single most important factor that limits the long-term survival …

Candidate genetic associations with acute GVHD (aGVHD) were evaluated with the use of
genotyped and imputed single-nucleotide polymorphism data from genome-wide scans of …

Rationale: Lung transplantation is characterized by very high rates of acute and chronic
allograft rejection. We hypothesize that activation of innate immunity augments adaptive …

Lung transplantation has developed significantly in recent years, but post-transplant care
and patients' survival still need to be improved. Moreover, organ shortage urges novel …