The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Background: Transient Receptor Potential (TRP) channels are non-selective Ca2+
permeable channels with a wide and dynamic involvement in the perception of …

Diabetes mellitus (DM) is a chronic syndrome involving neuropathic pain. Increased
oxidative stress in DM is assumed to increase free reactive oxygen radicals (ROS) and …

Background Clinical and experimental studies have pointed to the possible involvement of
the transient receptor potential ankyrin type-1 (TRPA1) channels in migraine pain. In this …

Preclinical data point to the contribution of transient receptor potential ankyrin 1 (TRPA1)
channels to the complex mechanisms underlying migraine pain. TRPA1 channels are …

Transient receptor potential ankyrin type-1 (TRPA1) channels are known to actively
participate in different pain conditions, including trigeminal neuropathic pain, whose clinical …

A series of novel amide derivatives of 1, 3-dimethyl-2, 6-dioxopurin-7-yl-alkylcarboxylic
acids designed using a structure-based computational approach was synthesized and …

The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in
pathophysiological processes that include asthma, cough, and inflammatory pain. Agonists …

Osteosarcoma is a heterogeneous tumor intimately linked to its microenvironment, which
promotes its growth and spread. It is generally accompanied by cancer-induced bone pain …

Objective To assess the functional effects of a variant, c. 89 G> A (p. Arg30Gln), in the
transient receptor potential melastatin 8 (TRPM8) cold-sensing, nonselective cation channel …