Pathogenesis of autoimmune disease
DS Pisetsky - Nature Reviews Nephrology, 2023 - nature.com
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …
and T cell reactivity to normal constituents of the host. These diseases occur widely and …
B cell depletion therapies in autoimmune disease: advances and mechanistic insights
DSW Lee, OL Rojas, JL Gommerman - Nature reviews Drug discovery, 2021 - nature.com
In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
B cell responses: cell interaction dynamics and decisions
JG Cyster, CDC Allen - Cell, 2019 - cell.com
B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …
physiology. Here, we review current understanding of how B cell responses are initiated; the …
Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus
R Kansal, N Richardson, I Neeli, S Khawaja… - Science translational …, 2019 - science.org
The failure of anti-CD20 antibody (Rituximab) as therapy for lupus may be attributed to the
transient and incomplete B cell depletion achieved in clinical trials. Here, using an …
transient and incomplete B cell depletion achieved in clinical trials. Here, using an …
Comparison of the response to rituximab between myelin oligodendrocyte glycoprotein and aquaporin‐4 antibody diseases
P Durozard, A Rico, C Boutiere, A Maarouf… - Annals of …, 2020 - Wiley Online Library
Objective To compare response to rituximab (RTX) between adult patients positive for
myelin oligodendrocyte glycoprotein (MOG) and aquaporin‐4 (AQP4) antibodies. Methods …
myelin oligodendrocyte glycoprotein (MOG) and aquaporin‐4 (AQP4) antibodies. Methods …
Dysregulated IFN-γ signals promote autoimmunity in STAT1 gain-of-function syndrome
AD Largent, K Lambert, K Chiang, N Shumlak… - Science Translational …, 2023 - science.org
Heterozygous signal transducer and activator of transcription 1 (STAT1) gain-of-function
(GOF) mutations promote a clinical syndrome of immune dysregulation characterized by …
(GOF) mutations promote a clinical syndrome of immune dysregulation characterized by …
Unveiling the proteome-wide autoreactome enables enhanced evaluation of emerging CAR T cell therapies in autoimmunity
A Bodansky, JL David, A Rallistan, M Kalaycioglu… - The Journal of clinical …, 2024 - jci.org
Given the global surge in autoimmune diseases, it is critical to evaluate emerging
therapeutic interventions. Despite numerous new targeted immunomodulatory therapies …
therapeutic interventions. Despite numerous new targeted immunomodulatory therapies …
B cell targeted therapies in autoimmune disease
Purpose of review FDA-approved B cell-targeted therapy has expanded to a multitude of
autoimmune diseases ranging from organ specific diseases, like pemphigus and multiple …
autoimmune diseases ranging from organ specific diseases, like pemphigus and multiple …
B Cell–Directed Therapy in Autoimmunity
I Abeles, C Palma, N Meednu, AS Payne… - Annual Review of …, 2024 - annualreviews.org
Autoimmune diseases with B cell–directed therapeutics approved by the US Food and Drug
Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this …
Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this …
Plasmacytoid dendritic cells and type I interferon promote extrafollicular B cell responses to extracellular self-DNA
Class-switched antibodies to double-stranded DNA (dsDNA) are prevalent and pathogenic
in systemic lupus erythematosus (SLE), yet mechanisms of their development remain poorly …
in systemic lupus erythematosus (SLE), yet mechanisms of their development remain poorly …