Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression

B Guo, M Zhang, W Hao, Y Wang, T Zhang… - Translational …, 2023 - nature.com
Mood disorders are associated with elevated inflammation, and the reduction of symptoms
after multiple treatments is often accompanied by pro-inflammation restoration. A variety of …

Gut microbial molecules in behavioural and neurodegenerative conditions

BD Needham, R Kaddurah-Daouk… - Nature Reviews …, 2020 - nature.com
Mounting evidence suggests that the gut microbiome impacts brain development and
function. Gut–brain connections may be mediated by an assortment of microbial molecules …

Imaging the role of inflammation in mood and anxiety-related disorders

JC Felger - Current neuropharmacology, 2018 - ingentaconnect.com
Background: Studies investigating the impact of a variety of inflammatory stimuli on the brain
and behavior have reported evidence that inflammation and release of inflammatory …

[HTML][HTML] Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?

GA Porter, JC O'Connor - World journal of psychiatry, 2022 - ncbi.nlm.nih.gov
Major depressive disorder is a debilitating disorder affecting millions of people each year.
Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk …

Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation

D Brites, A Fernandes - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Patients with chronic inflammation are often associated with the emergence of depression
symptoms, while diagnosed depressed patients show increased levels of circulating …

Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications

JC Felger, FE Lotrich - Neuroscience, 2013 - Elsevier
Mounting evidence indicates that inflammatory cytokines contribute to the development of
depression in both medically ill and medically healthy individuals. Cytokines are important …

Inflammation effects on motivation and motor activity: role of dopamine

JC Felger, MT Treadway - Neuropsychopharmacology, 2017 - nature.com
Motivational and motor deficits are common in patients with depression and other psychiatric
disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in …

Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity

F Calabrese, AC Rossetti, G Racagni… - Frontiers in cellular …, 2014 - frontiersin.org
Cytokines are key regulatory mediators involved in the host response to immunological
challenges, but also play a critical role in the communication between the immune and the …

Immunoception: the insular cortex perspective

A Rolls - Cellular & Molecular Immunology, 2023 - nature.com
To define the systemic neuroimmune interactions in health and disease, we recently
suggested immunoception as a term that refers to the existence of bidirectional functional …

New insights into the pivotal role of the amygdala in inflammation-related depression and anxiety disorder

P Hu, Y Lu, BX Pan, WH Zhang - International Journal of Molecular …, 2022 - mdpi.com
Depression and anxiety disorders are the two most prevalent psychiatric diseases that affect
hundreds of millions of individuals worldwide. Understanding the etiology and related …