The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential
structural component of a virion and facilitates many crucial life cycle steps through …

Regardless of the diversity of systems, allosteic signalling is found to be always caused by
perturbations. This recurring trait of allostery serves as a foundation for developing different …

The high mutation rate of the human immunodeficiency virus type 1 (HIV-1) plays a major
role in treatment resistance, from the development of vaccines to therapeutic drugs. In …

Retroviral Gag proteins are responsible for coordinating many aspects of virion assembly.
Gag possesses two distinct nucleic acid binding domains, matrix (MA) and nucleocapsid …

Therapeutic antibodies have shifted the paradigm of disease treatments from small
molecules to biologics, especially in cancer therapy. Despite the increasing number of …

The reductionist approach is prevalent in biomedical science. However, increasing evidence
now shows that biological systems cannot be simply considered as the sum of its parts. With …

The target of an antibody plays a significant role in the success of antibody-based
therapeutics and diagnostics, and vaccine development. This importance is focused on the …

HIV protease inhibitors against the viral protease are often hampered by drug resistance
mutations in protease and in the viral substrate Gag. To overcome this drug resistance and …

HIV-1 Gag polyprotein plays a pivotal role in assembly and budding of new particles, by
specifically packaging two copies of viral gRNA in the host cell cytoplasm and selecting the …

While drug resistant mutations in HIV-1 are largely credited to its error prone HIV-1 RT, the
time point in the infection cycle that these mutations can arise and if they appear …