Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Diosmetin (DSM), a newly discovered natural flavonoid, found in citrus plants and olive
leaves, has been reported to inhibit the progression of cancer when used as a food …

Glioma is the most common and malignant form of primary brain tumour, and is
characterised by high proliferation and extensive invasion and neurological destruction …

The abnormal expression or mutation of the plant homeodomain finger protein 14 (PHF14),
a recently discovered PHD finger protein, has been reported to link to a wide range of …

As a critical subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN),
CSN6 is upregulated in some human cancers and plays critical roles in tumorigenesis and …

Abstract Zinc finger protein 143 (ZNF143) belongs to the zinc finger protein family and
possesses transcription factor activity by binding sequence-specific DNA. The exact …

The mechanism underlying hypoxia-driven chromatin remodeling is a long-lasting question.
For the last two decades, this question has been resolved in part. It is now widely agreed …

The chromatin structure of the mammalian genome must facilitate both precisely-controlled
DNA replication together with tightly-regulated gene transcription. This necessarily involves …

Demethylzeylasteral is one of the extracts of Tripterygium wilfordii Hook F, which plays
important roles in multiple biological processes such as inflammation inhibition, as well as …