High throughput microscopy and single cell phenotypic image-based analysis in toxicology and drug discovery
Measuring single cell responses to the universe of chemicals (drugs, natural products,
environmental toxicants etc.) is of paramount importance to human health as phenotypic …
environmental toxicants etc.) is of paramount importance to human health as phenotypic …
3D cell cultures toward quantitative high-throughput drug screening
3D cell cultures are being utilized for drug discovery and development. However, there are
still challenges to implementing them generally in quantitative high-throughput screening …
still challenges to implementing them generally in quantitative high-throughput screening …
Dynamics of macrophage polarization support Salmonella persistence in a whole living organism
J Leiba, T Sipka, C Begon-Pescia, M Bernardello… - Elife, 2024 - elifesciences.org
Numerous intracellular bacterial pathogens interfere with macrophage function, including
macrophage polarization, to establish a niche and persist. However, the spatiotemporal …
macrophage polarization, to establish a niche and persist. However, the spatiotemporal …
[HTML][HTML] Artificial intelligence in imaging flow cytometry
Imaging flow cytometry (IFC) is a powerful screening technique that combines the
advantages of flow cytometry and optical microscopy (Basiji et al., 2007; Rees et al., 2022) …
advantages of flow cytometry and optical microscopy (Basiji et al., 2007; Rees et al., 2022) …
[HTML][HTML] A minimal-complexity light-sheet microscope maps network activity in 3D neuronal systems
PM Wysmolek, FD Kiessler, KA Salbaum… - Scientific Reports, 2022 - nature.com
In vitro systems mimicking brain regions, brain organoids, are revolutionizing the
neuroscience field. However, characterization of their electrical activity has remained a …
neuroscience field. However, characterization of their electrical activity has remained a …
Tissue optical clearing and 3D imaging of virus infections
DS Ushakov, S Finke - Advances in Virus Research, 2023 - Elsevier
Imaging pathogens within 3D environment of biological tissues provides spatial information
about their localization and interactions with the host. Technological advances in …
about their localization and interactions with the host. Technological advances in …
Novel biomedical imaging technology for high-resolution histological analysis
Rapid and high-accuracy histological analysis is a challenging yet appealing medical
pursuit. Recent advances in biomedical imaging technologies enable rapid and high …
pursuit. Recent advances in biomedical imaging technologies enable rapid and high …
[HTML][HTML] Multiple asters organize the yolk microtubule network during dclk2-GFP zebrafish epiboly
It is known that the organization of microtubule (MT) networks in cells is orchestrated by
subcellular structures named MT organizing centers (MTOCs). In this work, we use Light …
subcellular structures named MT organizing centers (MTOCs). In this work, we use Light …
Design and Build of a Customizable Light Sheet for Visualization of Cytoskeleton Networks
N Felcher, D Achiriloaie, B Lee, R McGorty… - arXiv preprint arXiv …, 2023 - arxiv.org
Reconstituted cytoskeleton composites have emerged as a valuable model system for
studying non equilibrium soft matter. Faithful capture of the dynamics of these three …
studying non equilibrium soft matter. Faithful capture of the dynamics of these three …
Author Spotlight: Advancing Knowledge in Far-From-Equilibrium Materials Through Light-Sheet Microscopy
N Felcher, D Achiriloaie, B Lee, R McGorty… - JoVE (Journal of …, 2024 - jove.com
Reconstituted cytoskeleton composites have emerged as a valuable model system for
studying non-equilibrium soft matter. The faithful capture of the dynamics of these 3D, dense …
studying non-equilibrium soft matter. The faithful capture of the dynamics of these 3D, dense …