Translation of acute ischemic stroke research to the clinical setting remains limited over the
last few decades with only one drug, recombinant tissue-type plasminogen activator …

The past two decades have seen a considerable rise in the use of sheep to model human
neurological disorders. While each animal model has its merits, sheep have many …

The Stroke Treatment Academic Industry Roundtable XII included a workshop to discuss the
most promising approaches to improve outcome from acute stroke. The workshop brought …

Background Serum albumin to globulin ratio (A/G) has been widely used as a representative
biomarker for assessing inflammation and nutrition status. However, in patients with acute …

Over decades of research into the treatment of stroke, nearly all attempts to translate
experimental treatments from discovery in cells and rodents to use in humans have failed …

Over decades, nearly all attempts to translate the benefits of therapeutic hypothermia in
stroke models of lower-order species to stroke patients have failed. Potentially overlooked …

Hypothermia is a promising neuroprotective treatment. This study aims to explore and
optimize the intervention scheme of intra-arterial hypothermia (IAH) in a middle cerebral …

Selective therapeutic cooling is a promising technique for reducing final infarct volume and
improving outcomes in ischemic stroke, especially as research regarding brain reperfusion …

Despite recent advances in acute stroke management, most patients experiencing a stroke
will suffer from residual brain damage and functional impairment. Addressing those residual …

Background Acute ischemic stroke (AIS) is the second leading cause of death globally.
Mechanical thrombectomy (MT) has improved patient prognosis but expedient treatment is …