Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …

In humans, the thyroid hormones T3 and T4 are synthesized in the thyroid gland in a
process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of …

Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …

Garrod's concept of 'chemical individuality'has contributed to comprehension of the
molecular origins of human diseases. Untargeted high-throughput metabolomic …

Genetic risk variants that have been identified in genome-wide association studies of
complex diseases are primarily non-coding. Translating these risk variants into mechanistic …

Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

The Study of Health in Pomerania (SHIP) comprises the two independent cohorts SHIP-
START (recruited between 1997 and 2001) and SHIP-TREND (recruited between 2008 to …

Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To
better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis …

Thyroid hormone (TH) plays a critical role in maintaining metabolic homeostasis throughout
life. It is well known that the liver and thyroid are intimately linked, with TH playing important …

Artificial intelligence (AI) has significantly impacted thyroid cancer diagnosis in recent years,
offering advanced tools and methodologies that promise to revolutionize patient outcomes …