Cellular pathways that contribute to adult human mammary gland architecture and lineages
have not been previously described. In this study, we identify a candidate stem cell niche in …

We have previously provided evidence showing an association between some precursor
lesions with low nuclear grade breast carcinomas (LNGBCs). In this study, further …

TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis upon binding to TRAIL
receptors 1 and 2 (TRAIL-R1/DR4 and TRAIL-R2/DR5). TRAIL-R3 (DcR1) and TRAIL-R4 …

Ethnopharmacological relevance Gypsophila elegans has been used as a traditional herbal
medicine for treating immune disorders and chronic liver diseases in China. The aim of this …

Normal human breast tissue consists of epithelial and nonepithelial cells with different
molecular profiles and differentiation grades. This molecular heterogeneity is known to yield …

Background Conjugated linoleic acid (CLA), a naturally occurring fatty acid found in
ruminant products such as milk and beef, has been shown to possess anti-cancer activities …

Columnar cell lesions (CCLs) are one of the most common abnormalities in the adult female
human breast, characterized by the presence of columnar-shaped epithelial cells lining …

Background Mammographic density is the third largest risk factor for ductal carcinoma in-situ
(DCIS) and invasive breast cancer. However, the question of whether risk-mediating …

Bcl-2, the protein product of the Bcl-2 gene, is a member of the Bcl-2 family of proteins that
play a crucial role in a complex mechanism of apoptosis. It was recently proposed that bcl-2 …

The anti-proliferative, cytotoxic and apoptogenic activities of delisheng, a Chinese medicinal
compound, has been investigated. In this study, the hepatocarcinoma cell line (HepG2) and …