Fragile X syndrome (FXS) results from a genetic mutation in a single gene yet produces a
phenotypically complex disorder with a range of neurological and psychiatric problems …

Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …

Autism covers a wide spectrum of disorders for which there are many views, hypotheses and
theories. Here we propose a unifying theory of autism, the Intense World Theory. The …

Ketamine exerts rapid antidepressant action in depressed and treatment-resistant
depressed patients within hours. At the same time, ketamine elicits a unique form of …

Despite the pronounced neurological deficits associated with mental retardation and autism,
it is unknown if altered neocortical circuit function occurs in these prevalent disorders. Here …

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the
leading monogenic cause of autism. The condition stems from loss of fragile X mental …

The activity-dependent structural and functional plasticity of dendritic spines has led to the
long-standing belief that these neuronal compartments are the subcellular sites of learning …

The age of an experimental animal can be a critical variable, yet age matters are often
overlooked within neuroscience. Many studies make use of young animals, without …

Alterations in sensory processing constitute prominent symptoms of fragile X syndrome;
however, little is known about how disrupted synaptic and circuit development in sensory …

Fragile X syndrome (FXS) is a neurodevelopmental disorder that causes intellectual
disability. It is a leading known genetic cause of autism. In addition to cognitive, social, and …