Transferrin-appended nanocaplet for transcellular siRNA delivery into deep tissues
Transferrin (Tf) is known to induce transcytosis, which is a consecutive endocytosis/
exocytosis event. We developed a Tf-appended nanocaplet (TfNC⊃ siRNA) for the purpose …
exocytosis event. We developed a Tf-appended nanocaplet (TfNC⊃ siRNA) for the purpose …
Intracellular photoactivation of caspase-3 by molecular glues for spatiotemporal apoptosis induction
NB Hentzen, R Mogaki, S Otake… - Journal of the American …, 2020 - ACS Publications
Caspase-3 (Casp-3) is an enzyme that efficiently induces apoptosis, a form of programmed
cell death. We report a dendritic molecular glue PCGlue that enables intracellular delivery of …
cell death. We report a dendritic molecular glue PCGlue that enables intracellular delivery of …
Molecular glue that spatiotemporally turns on protein–protein interactions
We developed a dendritic molecular glue PCGlue-NBD that can serve universally to “turn
on” protein–protein interactions (PPIs) spatiotemporally. PCGlue-NBD carrying multiple …
on” protein–protein interactions (PPIs) spatiotemporally. PCGlue-NBD carrying multiple …
Photoreactive molecular glue for enhancing the efficacy of DNA aptamers by temporary-to-permanent conjugation with target proteins
We developed a photoreactive molecular glue, BPGlue-N3, which can provide a universal
strategy to enhance the efficacy of DNA aptamers by temporary-to-permanent stepwise …
strategy to enhance the efficacy of DNA aptamers by temporary-to-permanent stepwise …
[PDF][PDF] Manipulation of Biomolecular Interactions with Molecular Glues and Their Biomedical Applications
茂垣里奈 - (No Title), 2019 - repository.dl.itc.u-tokyo.ac.jp
生物現象の根幹は生体分子間の結合/解離にある. 生物現象に関わる生体分子は,
ホルモンや神経伝達物質などの低分子化合物から, タンパク質や核酸といった生体高分子まで多岐 …
ホルモンや神経伝達物質などの低分子化合物から, タンパク質や核酸といった生体高分子まで多岐 …