Base excision repair (BER) corrects DNA damage from oxidation, deamination and
alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is …

In order to promote an efficient humoral immune response, germinal center B cells modify
both the antigen recognition and effector domains by programmed genetic alterations of …

Proteome-wide measurements of protein turnover have largely ignored the impact of post-
translational modifications (PTMs). To address this gap, we employ stable isotope labeling …

The base excision repair machinery protects DNA in cells from the damaging effects of
oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form …

Maintenance of a genome requires DNA repair integrated with chromatin remodeling. We
have analyzed six transcriptome data sets and one data set on translational regulation of …

DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar,
and single-strand break damage resulting from oxidation, alkylation, deamination, and …

In response to an assault by foreign organisms, peripheral B cells can change their antibody
affinity and isotype by somatically mutating their genomic DNA. The ability of a cell to modify …

Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much
progress has been made on elucidating critical roles for RPA in other DNA metabolic …

Base excision repair (BER) is an essential DNA repair pathway involved in the maintenance
of genome stability and thus in the prevention of human diseases, such as premature aging …

Endogenous and exogenous reactive species cause oxidatively induced DNA damage in
living organisms by a variety of mechanisms. As a result, a plethora of mutagenic and/or …