Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

Reversible methylation by means of N6-methyladenosine (m 6 A) is the most prevalent
internal modification in mammalian mRNA. This RNA chemical mark is created by proteins …

We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative
demethylation activity targeting the abundant N 6-methyladenosine (m6A) residues in RNA …

The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate-and Fe
(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein …

N 6-methyladenosine (m6A) is the most prevalent and internal modification that occurs in the
messenger RNAs (mRNA) of most eukaryotes, although its functional relevance remained a …

Although more than 100 types of RNA modification have been described thus far, most of
them were thought to be rare in mRNAs and in regulatory noncoding RNAs. Recent …

The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N 6-
methyladenosine (m6A) residues in mRNA in vitro and inside cells. FTO is the first RNA …

Posttranscriptionally modified nucleosides in RNA play integral roles in the cellular control of
biological information that is encoded in DNA. The modifications of RNA span all three …

N 6-methyladenosine (m 6 A) is a ubiquitous modification in mRNA and other RNAs across
most eukaryotes. For many years, however, the exact functions of m 6 A were not clearly …

Fe (II)/α-ketoglutarate (αKG)-dependent hydroxylases catalyze an amazing diversity of
reactions that result in protein side-chain modifications, repair of alkylated DNA/RNA …