The yin and yang of ERBB4: tumor suppressor and oncoprotein
ERBB4 (HER4) is a member of the ERBB family of receptor tyrosine kinases, a family that
includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 (Neu/HER2) …
includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 (Neu/HER2) …
The role of ErbB4 in cance r
VFM Segers, L Dugaucquier, E Feyen, H Shakeri… - Cellular oncology, 2020 - Springer
Background The epidermal growth factor receptor family consists of four members, ErbB1
(epidermal growth factor receptor-1), ErbB2, ErbB3, and ErbB4, which all have been found …
(epidermal growth factor receptor-1), ErbB2, ErbB3, and ErbB4, which all have been found …
[HTML][HTML] Chemotherapy-induced apoptosis, autophagy and cell cycle arrest are key drivers of synergy in chemo-immunotherapy of epithelial ovarian cancer
J Wahba, M Natoli, LM Whilding… - Cancer Immunology …, 2018 - Springer
Epithelial ovarian cancer (EOC) is the most lethal of all gynecological malignancies in the
UK. Recent evidence has shown that there is potential for immunotherapies to be successful …
UK. Recent evidence has shown that there is potential for immunotherapies to be successful …
Synergistic chemoimmunotherapy of epithelial ovarian cancer using ErbB-retargeted T cells combined with carboplatin
AC Parente-Pereira, LM Whilding, N Brewig… - The Journal of …, 2013 - journals.aai.org
Epithelial ovarian cancer (EOC) remains the most lethal gynecologic malignancy,
underscoring the need for better therapies. Adoptive immunotherapy using genetically …
underscoring the need for better therapies. Adoptive immunotherapy using genetically …
Genome-wide analysis of common copy number variation and epithelial ovarian cancer risk
Background: Germline DNA copy number variation (CNV) is a ubiquitous source of genetic
variation and remains largely unexplored in association with epithelial ovarian cancer (EOC) …
variation and remains largely unexplored in association with epithelial ovarian cancer (EOC) …
Advanced development of ErbB family-targeted therapies in osteosarcoma treatment
W Wang, H Zhao, T Yao, H Gong - Investigational new drugs, 2019 - Springer
Osteosarcoma (OS) is the most common primary aggressive and malignant bone tumor.
Newly diagnostic OS patients benefit from the standard therapy including surgical resection …
Newly diagnostic OS patients benefit from the standard therapy including surgical resection …
[HTML][HTML] ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms
JF Longo, SN Brosius, L Black, SH Worley… - Cell Communication and …, 2019 - Springer
Background We have found that erbB receptor tyrosine kinases drive Ras hyperactivation
and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However …
and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However …
[HTML][HTML] Overexpression of ERBB4 JM-a CYT-1 and CYT-2 isoforms in transgenic mice reveals isoform-specific roles in mammary gland development and …
VB Wali, M Gilmore-Hebert, R Mamillapalli… - Breast Cancer …, 2014 - Springer
Abstract Introduction Human Epidermal Growth Factor Receptor (ERBB4/HER4) belongs to
the Epidermal Growth Factor receptor/ERBB family of receptor tyrosine kinases. While …
the Epidermal Growth Factor receptor/ERBB family of receptor tyrosine kinases. While …
Targeting HER (ERBB) signaling in head and neck cancer: An essential update
HNC (head and neck cancer) remains the 6th most common carcinoma worldwide. The
suboptimal survival and toxicities observed with conventional approaches warrant …
suboptimal survival and toxicities observed with conventional approaches warrant …
[HTML][HTML] Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo
TO Nielsen, S Sorensen, F Dagnæs-Hansen… - British journal of …, 2013 - nature.com
Background: The tyrosine kinase receptor HER4 is a member of the epidermal growth factor
receptor (EGFR) family. It plays diverse roles in cancer development and cancer progression …
receptor (EGFR) family. It plays diverse roles in cancer development and cancer progression …