Antibiotic resistance remains a significant threat to modern medicine. Modification of the
antibiotic target is a resistance strategy that is increasingly prevalent among pathogens …

Predicting the effects of organic compounds on environments and biological systems is an
important objective for environmental chemistry and human health. The logarithm (to base …

The rise of multidrug-resistant bacterial infections is a cause of global concern. There is an
urgent need to both revitalize antibacterial agents that are ineffective due to resistance while …

RNA methyltransferases (MTases) are ubiquitous enzymes whose hitherto low profile in
medicinal chemistry, contrasts with the surging interest in RNA methylation, the arguably …

Ribosomes, which synthesize proteins, are critical organelles for the survival and growth of
bacteria. About 60% of approved antibiotics discovered so far combat pathogenic bacteria …

Many antibiotics available in the clinic today directly inhibit bacterial translation. Despite the
past success of such drugs, their efficacy is diminishing with the spread of antibiotic …

Tuberculosis (TB) is an airborne infectious disease caused by Mycobacterium tuberculosis
(M. tb) whose natural history traces back to 70,000 years. TB remains a major global health …

Mycobacterium tuberculosis (M. tb) remains a formidable global health threat. The
increasing drug resistance among M. tb clinical isolates is exacerbating the current …

Methylated chemicals are widely used as key intermediates for the syntheses of
pharmaceuticals, fragrances, flavors, biofuels and plastics. In nature, the process of …

Background: The great emergence of multi-resistant bacterial strains and the low renewal of
antibiotics molecules are leading human and veterinary medicine to certain therapeutic …