Increased survival in patients with β thalassemia major (TM) allowed for several
complications of the disease and its treatment to manifest, one of which is bone disease …

Bone disorders in patients with thalassemia major (TM) and intermedia (TI) constitute
complex conditions that result from various factors affecting the growing skeleton. Although …

Adults with β thalassemia major frequently have low BMD, fractures, and bone pain. The
purpose of this study was to determine the prevalence of low BMD, fractures, and bone pain …

Calcitonin-gene-related peptide (CGRP) is a neuropeptide, which is widely distributed
throughout the central and peripheral nervous systems. Numerous mechanisms underlying …

Osteoporosis may complicate iron overload diseases such as genetic hemochromatosis.
However, molecular mechanisms involved in the iron-related osteoporosis remains poorly …

The coupling of bone formation and resorption is mediated through the OPG/RANK/RANKL
system. OPG and RANKL are mainly produced by osteoblasts but also a variety of other …

Aim: The aim of the experiment was to investigate the levels of free soluble receptor activator
of nuclear factor‐κb ligand (sRANKL) in periodontal health and disease and their …

Study Design. Literature review. Objective. To present a comprehensive overview of spinal
involvement in patients with β-thalassemia, aiming to orient the spinal surgeon to these …

The receptor activator of NF-κB ligand (RANKL) is a member of the TNF receptor
superfamily, essential for osteoclastogenesis. It binds to its receptor activator of NF-κB on the …

Hematopoietic disorders, particularly hemolytic anemias, commonly lead to bone loss. We
have previously reported that actively proliferating cancer cells stimulate osteoclastogenesis …