Defining and combating antibiotic resistance from One Health and Global Health perspectives

S Hernando-Amado, TM Coque, F Baquero… - Nature …, 2019 - nature.com
Several interconnected human, animal and environmental habitats can contribute to the
emergence, evolution and spread of antibiotic resistance, and the health of these contiguous …

Mobile genetic elements associated with antimicrobial resistance

SR Partridge, SM Kwong, N Firth… - Clinical microbiology …, 2018 - Am Soc Microbiol
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …

Genomics and pathotypes of the many faces of Escherichia coli

J Geurtsen, M de Been, E Weerdenburg… - FEMS microbiology …, 2022 - academic.oup.com
Escherichia coli is the most researched microbial organism in the world. Its varied impact on
human health, consisting of commensalism, gastrointestinal disease, or extraintestinal …

The global distribution and spread of the mobilized colistin resistance gene mcr-1

R Wang, L Van Dorp, LP Shaw, P Bradley… - Nature …, 2018 - nature.com
Colistin represents one of the few available drugs for treating infections caused by
carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of …

Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China

Z Peng, Z Hu, Z Li, X Zhang, C Jia, T Li, M Dai… - Nature …, 2022 - nature.com
The expanding use of antimicrobials in livestock is an important contributor to the worldwide
rapid increase in antimicrobial resistance (AMR). However, large-scale studies on AMR in …

Worldwide Prevalence of mcr-mediated Colistin-Resistance Escherichia coli in Isolates of Clinical Samples, Healthy Humans, and Livestock—A Systematic Review …

C Bastidas-Caldes, JH de Waard, MS Salgado… - Pathogens, 2022 - mdpi.com
Background: Antimicrobial resistance is a serious public-health problem throughout the
world. Escherichia coli, the most common Gram-negative microorganism, has developed …

Distinct increase in antimicrobial resistance genes among Escherichia coli during 50 years of antimicrobial use in livestock production in China

L Yang, Y Shen, J Jiang, X Wang, D Shao, MMC Lam… - Nature Food, 2022 - nature.com
Antimicrobial use in livestock production is linked to the emergence and spread of
antimicrobial resistance (AMR), but large-scale studies on AMR changes in livestock …

Plasmid-mediated resistance is going wild

M Dolejska, CC Papagiannitsis - Plasmid, 2018 - Elsevier
Multidrug resistant (MDR) Gram-negative bacteria have been increasingly reported in
humans, companion animals and farm animals. The growing trend of plasmid-mediated …

Ultrafast search of all deposited bacterial and viral genomic data

P Bradley, HC Den Bakker, EPC Rocha… - Nature …, 2019 - nature.com
Exponentially increasing amounts of unprocessed bacterial and viral genomic sequence
data are stored in the global archives. The ability to query these data for sequence search …

H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity

SP Methot, J Padeken, G Brancati, P Zeller… - Nature cell …, 2021 - nature.com
The developmental role of histone H3K9 methylation (H3K9me), which typifies
heterochromatin, remains unclear. In Caenorhabditis elegans, loss of H3K9me leads to a …