The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD)
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …

The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of
bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with …

The microbial population residing within the human gut represents one of the most densely
populated microbial niche in the human body with growing evidence showing it playing a …

Suicide is the second leading cause of death worldwide for adolescents. Despite decades of
research on correlates and risk factors for adolescent suicide, we know little about why …

The cerebral folate receptor alpha (FRα) transports 5-methyltetrahydrofolate (5-MTHF) into
the brain; low 5-MTHF in the brain causes cerebral folate deficiency (CFD). CFD has been …

Major Depressive Disorder (MDD) is a highly prevalent psychiatric disorder worldwide. It
causes individual suffering, loss of productivity, increased health care costs and high suicide …

Background Previous research suggested that folate levels play an important role in the
etiology and course of depression. However, the literature has been inconsistent with regard …

Importance Suicide is a leading cause of death in the United States, having increased more
than 30% from 2000 to 2018. An inexpensive, safe, widely available treatment for preventing …

Introduction Pteridines, such as neopterin, biopterin, and tetrahydrobiopterin (BH 4), may be
involved in depression pathophysiology owing to their links to immune-inflammatory …