Apical periodontitis caused by root canal infection is the most frequent pathological lesion in
the jaws, mainly manifested as periapical granulomas and cysts. Understanding of the …

The immune system is an extremely complex biological network that plays a crucial role in
the hemostasis of periapical tissue, pathogenesis of apical periodontitis (AP), and periapical …

Apical periodontitis (AP) is an inflammation affecting the periapical region of tooth root.
Microbial pathogens activate inflammasomes and promote the production of pro …

Objectives The aim of this study was to evaluate the effects of Hiflow with other two kinds of
root canal sealers on the biological behavior of stem cells from the apical papilla (SCAP) …

Abstract Background Interleukin 1 (IL-1) is involved in bone resorption. However, the role of
IL-1 in periapical lesions characterized by periapical bone destruction in primary teeth has …

Aim The aim of the study was to evaluate the effect of systemic curcumin administration on
the severity of apical periodontitis (AP). Methodology Forty male Wistar rats weighing 250 …

Abstract Introduction Periapical lesions (PLs) are common inflammatory diseases primarily
caused by microbial infections within root canals. These infections trigger complex immune …

Introduction The exact mechanisms of periapical bone resorption have not been fully
elucidated. This study aimed to analyze the expression of Notch signaling molecules …

Objective: This study evaluated the expression of pro-inflammatory (IL-1β, IL-6, IFN-γ and
TNF-α) and anti-inflammatory (IL-4 and TGF-β) cytokines in apical periodontitis lesions …

Aim To explore the function and mechanisms of NLRP 6 (NOD‐, LRR‐and pyrin domain‐
containing 6) in the inflammatory response of human periodontal ligament cells (HPDLC s) …