Nuclear mRNA export plays an important role in gene expression. We describe the
mechanisms of mRNA export including the importance of mRNP assembly, docking with the …

Expression of protein-coding genes in eukaryotes relies on the coordinated action of many
sophisticated molecular machineries. Transcription produces precursor mRNAs (pre …

Cells infected by influenza virus mount a large-scale antiviral response and most cells
ultimately initiate cell-death pathways in an attempt to suppress viral replication. We …

The nucleus represents a cellular compartment where the discrimination of self from non-self
nucleic acids is vital. While emerging evidence establishes a nuclear non-self DNA sensing …

Severe acute respiratory syndrome coronavirus nonstructural protein 1 (nsp1) is a key factor
in virus-induced down-regulation of host gene expression. In infected cells, nsp1 engages in …

Influenza viruses are respiratory pathogens that represent a significant threat to public
health, despite the large-scale implementation of vaccination programs. It is necessary to …

Many DNA and a few RNA viruses use the host cell nucleus for virion formation and/or
genome replication. To this end, the nuclear envelope (NE) barrier has to be overcome for …

The life cycle of influenza A virus (IAV) is modulated by various cellular host factors.
Although previous studies indicated that IAV infection is controlled by HDAC6, the …

Live-attenuated influenza A viruses (LAIV) may be superior to inactivated or subunit
vaccines since they can be administered via mucosal routes to induce local immunity in the …

Viruses threaten humans, livestock, and plants, and are difficult to combat. Imaging of
viruses by light microscopy is key to uncover the nature of known and emerging viruses in …