Insights into N6-methyladenosine and programmed cell death in cancer

L Liu, H Li, D Hu, Y Wang, W Shao, J Zhong, S Yang… - Molecular cancer, 2022 - Springer
Abstract N6-methyladenosine (m6A) methylation, the most common form of internal RNA
modification in eukaryotes, has gained increasing attention and become a hot research topic …

Caspase‐8: A key protein of cross‐talk signal way in “PANoptosis” in cancer

M Jiang, L Qi, L Li, Y Wu, D Song… - International journal of …, 2021 - Wiley Online Library
Cysteinyl aspartate specific proteinase (Caspase)‐8 has long been considered a promoter
of apoptosis and part of the mechanism by which cytotoxic drugs kill cancer cells. With the …

Crosstalk among m6A RNA methylation, hypoxia and metabolic reprogramming in TME: from immunosuppressive microenvironment to clinical application

F Zhang, H Liu, M Duan, G Wang, Z Zhang… - Journal of hematology & …, 2022 - Springer
The tumor microenvironment (TME), which is regulated by intrinsic oncogenic mechanisms
and epigenetic modifications, has become a research hotspot in recent years. Characteristic …

[HTML][HTML] Recognition of necroptosis: From molecular mechanisms to detection methods

T Zhu, BW Wu - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Necroptosis is a crucial modality of programmed cell death characterized by distinct
morphological and biochemical hallmarks, including cell membrane rupture, organelle …

Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma

T Lomphithak, P Akara-Amornthum, K Murakami… - Scientific reports, 2021 - nature.com
Necroptosis, a regulated form of necrosis, has emerged as a novel therapeutic strategy that
could enhance cancer immunotherapy. However, its role in tumorigenesis is still debated …

In Vitro Anticancer Activity and Oxidative Stress Biomarkers Status Determined by Usnea barbata (L.) FH Wigg. Dry Extracts

V Popovici, L Bucur, G Vochita, D Gherghel, CT Mihai… - Antioxidants, 2021 - mdpi.com
Lichens represent an important resource for common traditional medicines due to their
numerous metabolites that can exert diverse pharmacological activities including anticancer …

Understanding necroptosis in pancreatic diseases

R He, Z Wang, S Dong, Z Chen, W Zhou - Biomolecules, 2022 - mdpi.com
Intermediate between apoptosis and necrosis, necroptosis is a regulated caspase-
independent programmed cell death that induces an inflammatory response and mediates …

Identification of a necroptosis-related gene signature as a novel prognostic biomarker of cholangiocarcinoma

L Xu, X Gao, J Xing, Z Guo - Frontiers in Immunology, 2023 - frontiersin.org
Background Cholangiocarcinoma (CHOL) is the most prevalent type of malignancy and the
second most common form of primary liver cancer, resulting in high rates of morbidity and …

[HTML][HTML] The Impact of Biliary Injury on the Recurrence of Biliary Cancer and Benign Disease after Liver Transplantation: Risk Factors and Mechanisms

CJ Wehrle, R Panconesi, S Satish, M Maspero, C Jiao… - Cancers, 2024 - mdpi.com
Simple Summary Ischemia-reperfusion injury (IRI) is the source of significant graft
inflammation in liver transplantation. Such injuries can lead to increased recurrence of both …

[HTML][HTML] Tumor microenvironment: Necroptosis switches the subtype of liver cancer while necrosis promotes tumor recurrence and progression

BH Özdemir - Exp Clin Transplant, 2022 - ectrx.org
Liver cancer is a heterogeneous group of solid tumors that include mainly epithelial tumors.
As with other solid carcinomas, tumor development results from an accumulation of genetic …