Designing materials to direct stem-cell fate
MP Lutolf, PM Gilbert, HM Blau - Nature, 2009 - nature.com
Proper tissue function and regeneration rely on robust spatial and temporal control of
biophysical and biochemical microenvironmental cues through mechanisms that remain …
biophysical and biochemical microenvironmental cues through mechanisms that remain …
[HTML][HTML] The extracellular matrix of hematopoietic stem cell niches
C Lee-Thedieck, P Schertl, G Klein - Advanced Drug Delivery Reviews, 2022 - Elsevier
Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …
TrackMate 7: integrating state-of-the-art segmentation algorithms into tracking pipelines
TrackMate is an automated tracking software used to analyze bioimages and is distributed
as a Fiji plugin. Here, we introduce a new version of TrackMate. TrackMate 7 is built to …
as a Fiji plugin. Here, we introduce a new version of TrackMate. TrackMate 7 is built to …
Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodelling
Neural progenitor cell (NPC) culture within three-dimensional (3D) hydrogels is an attractive
strategy for expanding a therapeutically relevant number of stem cells. However, relatively …
strategy for expanding a therapeutically relevant number of stem cells. However, relatively …
Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture
Stem cells that naturally reside in adult tissues, such as muscle stem cells (MuSCs), exhibit
robust regenerative capacity in vivo that is rapidly lost in culture. Using a bioengineered …
robust regenerative capacity in vivo that is rapidly lost in culture. Using a bioengineered …
Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
N Vannini, M Girotra, O Naveiras, G Nikitin… - Nature …, 2016 - nature.com
Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on
anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy …
anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy …
Bringing TrackMate into the era of machine-learning and deep-learning
TrackMate is an automated tracking software used to analyze bioimages and distributed as
a Fiji plugin. Here we introduce a new version of TrackMate rewritten to improve …
a Fiji plugin. Here we introduce a new version of TrackMate rewritten to improve …
In situ cell manipulation through enzymatic hydrogel photopatterning
KA Mosiewicz, L Kolb, AJ Van Der Vlies, MM Martino… - Nature materials, 2013 - nature.com
The physicochemical properties of hydrogels can be manipulated in both space and time
through the controlled application of a light beam. However, methods for hydrogel …
through the controlled application of a light beam. However, methods for hydrogel …
Artificial niche microarrays for probing single stem cell fate in high throughput
To understand the regulatory role of niches in maintaining stem-cell fate, multifactorial in
vitro models are required. These systems should enable analysis of biochemical and …
vitro models are required. These systems should enable analysis of biochemical and …
Prospective identification of hematopoietic lineage choice by deep learning
F Buggenthin, F Buettner, PS Hoppe, M Endele… - Nature …, 2017 - nature.com
Differentiation alters molecular properties of stem and progenitor cells, leading to changes in
their shape and movement characteristics. We present a deep neural network that …
their shape and movement characteristics. We present a deep neural network that …