The E2F family of transcription factors (E2Fs) consist of eight genes in mammals. These
genes encode ten proteins that are usually classified as transcriptional activators or …

The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-
E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating …

E2F transcription factors play critical roles in the cell cycle. Therefore, their activity is
expected to reflect tumor aggressiveness and responsiveness to therapy. We scored 3905 …

E2Fs are a family of pivotal transcription factors. Accumulative evidence indicates that
aberrant expression or activation of E2Fs is a common phenomenon in malignances, and …

Fungal endophytes have established new paradigms in the area of biomedicine due to their
ability to produce metabolites of pharmacological importance. The present study reports the …

Abstract NF-Y is a CCAAT-binding trimeric transcription factor, whose regulome, interactome
and oncogenic potential point to direct involvement in cellular transformation. Yet little is …

E2F8 is a multifaceted transcription factor that plays a crucial role in mediating the hallmarks
of cancer, including sustaining proliferative signaling, resisting cell death, and activating …

Both pro-oncogenic and anti-oncogenic effects of E2F2 have been revealed in different
malignancies. However, the precise role of E2F2 in pancreatic cancer, in particular in …

Dysregulation of microRNAs (miRNAs) exerts key roles in the development of pancreatic
cancer (PCa). miR-26a is reportedly a tumor suppressor in cancers. However, whether miR …

The E2F transcription factor family, a cellular factor required for activation of the E2
adenoviral promoter (1), came to the forefront of cancer research when it was found to be …