The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the
primary structure for the perception of sound. Along the length of the cochlear spiral is the …

The inner ear is one of the most morphologically elaborate tissues in vertebrates, containing
a group of mechanosensitive sensory organs that mediate hearing and balance. These …

Mammalian hearing requires the development of the organ of Corti, a sensory epithelium
comprising unique cell types. The limited number of each of these cell types, combined with …

Cochlear hair cells (HCs) in the inner ear are responsible for sound detection. For HC fate
specification, the master transcription factor Atoh1 is both necessary and sufficient. Atoh1 …

The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and
orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a …

Inner ear disorders are among the most common congenital abnormalities; however, current
tissue culture models lack the cell type diversity to study these disorders and normal otic …

The mammalian cochlea is a remarkable sensory organ, capable of perceiving sound over a
range of 1012 in pressure, and discriminating both infrasonic and ultrasonic frequencies in …

While inner ear disorders are common, our ability to intervene and recover their sensory
function is limited. In vitro models of the inner ear, like the organoid system, could aid in …

Deafness caused by the terminal loss of inner ear hair cells is one of the most common
sensory diseases. However, nonmammalian animals (eg, birds, amphibians, and fish) …

In mammals, hearing loss is irreversible due to the lack of regenerative potential of non-
sensory cochlear cells. Neonatal cochlear cells, however, can grow into organoids that …