The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other
bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and …

Bioorthogonal cleavage chemistry has been rapidly emerging as a powerful tool for
manipulation and gain-of-function studies of biomolecules in living systems. While the initial …

While the Staudinger reaction has first been described a hundred years ago in 1919, the
ligation reaction became one of the most important and efficient bioconjugation techniques …

Bioorthogonal chemical reactions are a thriving area of chemical research in recent years as
an unprecedented technique to dissect native biological processes through chemistry …

In the two decades since the introduction of the “click chemistry” concept, the toolbox of “click
reactions” has continually expanded, enabling chemists, materials scientists, and biologists …

Bioorthogonal chemistry involves selective biocompatible reactions between functional
groups that are not normally present in biology. It has been used to probe biomolecules in …

Bioorthogonal phosphines were introduced in the context of the Staudinger ligation over 20
years ago. Since that time, phosphine probes have been used in myriad applications to tag …

Hydrogels are commonly used as engineered extracellular matrix (ECM) mimics in
applications ranging from tissue engineering to in vitro disease models. Ideal mechanisms …

Bioorthogonal chemistry, referring to chemical reactions occurring in a physiological
environment without interfering with native biochemical reactions, has witnessed substantial …

Selective manipulation of protein kinases under living conditions is highly desirable yet
extremely challenging, particularly in a gain-of-function fashion. Here we employ our …