Recent research has demonstrated that survivors of childhood cancer are at risk for a myriad
of late effects that affect physical and mental quality of life. We discuss the patterns and …

The late neurocognitive and psychosocial effects of treatment for pediatric brain tumor (PBT)
represent important areas of clinical focus and ongoing research. Neurocognitive sequelae …

Background Young children with medulloblastoma have a poor overall survival compared
with older children, due to use of radiation-sparing therapy in young children. Radiotherapy …

Purpose Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group
3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical …

Purpose To assess the prevalence and severity of neurocognitive impairment in adult
survivors of pediatric CNS tumors and to examine associated treatment exposures. Patients …

Major advances in high precision treatment delivery and imaging have greatly improved the
tolerance of radiotherapy (RT); however, the selective sparing of normal tissue and the …

Young adult childhood cancer survivors are at an increased risk of frailty, a physiologic
phenotype typically found among older adults. This phenotype is associated with new‐onset …

Background. Medulloblastoma is the most common malignant childhood brain tumor,
although long-term risks for chronic neurologic health and psychosocial functioning in aging …

Simple Summary Radiation therapy-related brain damage with neurocognitive impairment is
a common long-term side effect in cancer survivors and significantly impairs the quality of …

Advances in multimodality therapy have led to childhood cancer cure rates over 80%.
However, surgery, chemotherapy, and radiotherapy may lead to debilitating or even fatal …