A historical review of brain drug delivery
WM Pardridge - Pharmaceutics, 2022 - mdpi.com
The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …
Applications and evolution of melittin, the quintessential membrane active peptide
Melittin, the main venom component of the European Honeybee, is a cationic linear peptide-
amide of 26 amino acid residues with the sequence: GIGAVLKVLTTGLPALISWIKRKRQQ …
amide of 26 amino acid residues with the sequence: GIGAVLKVLTTGLPALISWIKRKRQQ …
Antimicrobial peptides/ciprofloxacin-loaded O-carboxymethyl chitosan/self-assembling peptides hydrogel dressing with sustained-release effect for enhanced anti …
Y Huan, Q Kong, Q Tang, Y Wang, H Mou, R Ying… - Carbohydrate …, 2022 - Elsevier
Bacteria-induced wound infections and multifunctional hydrogels have received widespread
attention in wound repair. In this study, self-assembling peptides (SAPs) were grafted on O …
attention in wound repair. In this study, self-assembling peptides (SAPs) were grafted on O …
Peptide shuttles for blood–brain barrier drug delivery
M Sánchez-Navarro, E Giralt - Pharmaceutics, 2022 - mdpi.com
The blood–brain barrier (BBB) limits the delivery of therapeutics to the brain but also
represents the main gate for nutrient entrance. Targeting the natural transport mechanisms …
represents the main gate for nutrient entrance. Targeting the natural transport mechanisms …
Cutting-edge advances in modeling the blood–brain barrier and tools for its reversible permeabilization for enhanced drug delivery into the brain
The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required
for maintaining the executive functions of the central nervous system (CNS). Tight control of …
for maintaining the executive functions of the central nervous system (CNS). Tight control of …
Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer's disease-like neuroinflammation triggered by periodontal disease
Introduction Periodontitis-related oral microbial dysbiosis is thought to contribute to
Alzheimer's disease (AD) neuroinflammation and brain amyloid production. Since probiotics …
Alzheimer's disease (AD) neuroinflammation and brain amyloid production. Since probiotics …
Modulating the blood–brain barrier: a comprehensive review
The highly secure blood–brain barrier (BBB) restricts drug access to the brain, limiting the
molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic …
molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic …
The blood-brain barrier, a Key Bridge to treat neurodegenerative diseases
Z Hang, L Zhou, C Xing, Y Wen, H Du - Ageing Research Reviews, 2023 - Elsevier
As a highly selective and semi-permeable barrier that separates the circulating blood from
the brain and central nervous system (CNS), the blood-brain barrier (BBB) plays a critical …
the brain and central nervous system (CNS), the blood-brain barrier (BBB) plays a critical …
Tissue‐Engineered Microvessels: A Review of Current Engineering Strategies and Applications
Microvessels, including arterioles, capillaries, and venules, play an important role in
regulating blood flow, enabling nutrient and waste exchange, and facilitating immune …
regulating blood flow, enabling nutrient and waste exchange, and facilitating immune …
Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy
RM Linville, PC Searson - Fluids and Barriers of the CNS, 2021 - Springer
With the limitations associated with post-mortem tissue and animal models, In vitro BBB
models enable precise control of independent variables and microenvironmental cues, and …
models enable precise control of independent variables and microenvironmental cues, and …