Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development
and disease through their regulation of transcription, RNA processing and translation …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Biomolecular condensates participate in the regulation of gene transcription, yet the
relationship between nuclear condensation and transcriptional activation remains elusive …

BCL11A, the major regulator of fetal hemoglobin (HbF, α2γ2) level, represses γ-globin
expression through direct promoter binding in adult erythroid cells in a switch to adult …

Around birth, globin expression in human red blood cells (RBCs) shifts from γ-globin to β-
globin, which results in fetal haemoglobin (HbF, α2γ2) being gradually replaced by adult …

The benign condition hereditary persistence of fetal hemoglobin (HPFH) is known to
ameliorate symptoms of co-inherited β-hemoglobinopathies, such as sickle cell disease and …

Pinpointing functional noncoding DNA sequences and defining their contributions to health-
related traits is a major challenge for modern genetics. We developed a high-throughput …

Long non-coding RNAs (lncRNAs) represent a major fraction of the transcriptome in
multicellular organisms. Although a handful of well-studied lncRNAs are broadly recognized …

Sickle cell disease (SCD) is a heritable disorder caused by β-globin gene mutations.
Induction of fetal γ-globin is an established therapeutic strategy. Recently, epigenetic …

Over the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to
the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically …