Objective To determine the comparative effectiveness of exercise versus drug interventions
on mortality outcomes. Design Metaepidemiological study. Eligibility criteria Meta-analyses …

Objective Demographic changes are increasing the pressure to improve therapeutic
strategies against cognitive decline in Alzheimer disease (AD) and mild cognitive …

Objective To determine the availability of data on overall survival and quality of life benefits
of cancer drugs approved in Europe. Design Retrospective cohort study. Setting Publicly …

Introduction: Substandard and falsified medicines undermine health systems. We sought to
unravel the political and economic factors which drive the production of these products, and …

Promising evidence from clinical studies of drug effects does not always translate to
improvements in patient outcomes. In this review, we discuss why early evidence is often ill …

“Adaptive pathways” to drug authorisation: adapting to industry? Page 1 “Adaptive pathways” to
drug authorisation: adapting to industry? Evidence for benefits to patients and public health of …

Why the drug development pipeline is not delivering better medicines | The BMJ Skip to main
content Intended for healthcare professionals Access provided by Google Indexer Subscribe …

Background The current drug development paradigm has been criticized for being too drug-
centered and for not adequately focusing on the patients who will eventually be …

A recent review of the clinical trial literature20—set out to help prescribers in selecting a first-
line statin—highlighted the essential role of network meta-analysis methods in synthesizing …

This paper examines whether there is a switch in total (originator and generic) consumption
after generic entry from molecules that face generic competition towards other molecules of …